ISSN 2074-9414 (Print),
ISSN 2313-1748 (Online)

Global Biomaterials Market: Potential Opportunities for Raw Materials of Animal Origin

Abstract
Introduction. Meat processing enterprises are facing the problem of utilization of secondary products with a limited scope of application and a wide range of useful properties. One of the promising ways of slaughter-house by-product utilization is the production of biomaterials that can replace various tissues of a living organism. This review presents an analysis of the global biomaterials market, its volume, and possible ways of using secondary meat resources in various sectors of economy. Study objects and methods. The article represents some results of a desk research based on open sources, i.e. publications and Internet data portals. Results and discussion. One of the most important tasks of modern regenerative medicine is to develop fast and effective methods for the restoration of damaged or lost organs and tissue fragments. Its solution directly depends on new advanced biomaterials. Modern biocompatible materials are in great demand in such areas of medicine as orthopedics, ophthalmology, dentistry, general and cardiovascular surgery, restorative medicine, drug delivery, etc. Cosmetology is a rapidly evolving segment of medicine and depends on such biomaterials as hyaluronic acid and collagen. Russian biomedicine occupies 0.7% of the world market. However, the Russian segment is likely to grow and expand its range of biomaterials. Conclusion. The currently unused resources of meat industry can be an excellent source of valuable raw materials for the advanced biomedical structures used in tissue engineering. A wide variety of structures and properties of secondary resources can produce a wide range of biomaterials. The possibility of manufacturing matrices from internally sourced raw materials within one enterprise is particularly promising.
Keywords
Meat industry, secondary meat raw materials, biomaterials, biomaterials market, biomedicine
REFERENCES
  1. Lisitsyn AB, Neburchilova NF, Petrunina IV. Complex use of raw material in the meat sector of the agro-industrial complex. Food Industry. 2016;(5):58–62. (In Russ.).
  2. Sivashanmugam A, Kumar RA, Priya MV, Nair SV, Jayakumar R. An overview of injectable polymeric hydrogels for tissue engineering. European Polymer Journal. 2015;72:543–565. https://doi.org/10.1016/j.eurpolymj.2015.05.014.
  3. Biomaterials market size, share & trends analysis report by product (natural, metallic, ceramics, polymers), by application (cardiovascular, orthopedics, plastic surgery), and segment forecasts, 2020–2027. Grand View Research; 2010. 190 p.
  4. Sevastianov VI. Technologies of tissue engineering and regenerative medicine. Russian Journal of Transplantology and Artificial Organs. 2014;16(3):93–108. (In Russ.). https://doi.org/10.15825/1995-1191-2014-3-93-108.
  5. Liu J, Li B, Jing H, Wu Y, Kong D, Leng X, et al. Swim bladder as a novel biomaterial for cardiovascular materials with anti-calcification properties. Advanced Healthcare Materials. 2020;9(2). https://doi.org/10.1002/adhm.201901154.
  6. Nichay NR, Zhuravleva IY, Kulyabin YuY, Zubritskiy AV, Voitov AV, Soynov IA, et al. Diepoxy-versus glutaraldehydetreated xenografts: outcomes of right ventricular outflow tract reconstruction in children. World Journal for Pediatric and Congenital Heart Surgery. 2020;11(1):56–64. https://doi.org/10.1177/2150135119885900.
  7. Blatchley MR, Gerecht S. Reconstructing the vascular developmental milieu in vitro. Trends in Cell Biology. 2020;30(1):15–31. https://doi.org/10.1016/j.tcb.2019.10.004.
  8. Dastagir K, Dastagir N, Limbourg A, Reimers K, Strauss S, Vogt PM. In vitro construction of artificial blood vessels using spider silk as a supporting matrix. Journal of the Mechanical Behavior of Biomedical Materials. 2020;101. https://doi.org/10.1016/j.jmbbm.2019.103436.
  9. Ke X, Li M, Wang X, Liang J, Wang X, Wu S, et al. An injectable chitosan/dextran/β-glycerophosphate hydrogel as cell delivery carrier for therapy of myocardial infarction. Carbohydrate Polymers. 2020;229. https://doi.org/10.1016/j.carbpol.2019.115516.
  10. Maroni A, Melocchi A, Zema L, Foppoli A, Gazzaniga A. Retentive drug delivery systems based on shape memory materials. Journal of Applied Polymer Science. 2020;137(25). https://doi.org/10.1002/app.48798.
  11. Blum C, Schlegelmilch K, Schilling T, Shridhar A, Rudert M, Jakob F, et al. Extracellular matrix-modified fiber scaffolds as a proadipogenic mesenchymal stromal cell delivery platform. ACS Biomaterials Science and Engineering. 2019;5(12):6655–6666. https://doi.org/10.1021/acsbiomaterials.9b00894.
  12. Motiei M, Munster L. Stabilization of chitosan-based polyelectrolyte nanoparticle cargo delivery biomaterials by a multiple ionic cross-linking strategy. Carbohydrate Polymers. 2020;231. https://doi.org/10.1016/j.carbpol.2019.115709.
  13. Reis RL, Neves NM. Challenges and opportunities of natural biomaterials for advanced devices and therapies. In: Neves NM, Reis RL, editors. Biomaterials from nature for advanced devices and therapies. Wiley Blackwell; 2016. pp. 629–633 https://doi.org/10.1002/9781119126218.ch33.
  14. Lalzawmliana V, Anand A, Roy M, Kundu B, Nandi SK. Mesoporous bioactive glasses for bone healing and biomolecules delivery. Materials Science and Engineering C. 2020;106. https://doi.org/10.1016/j.msec.2019.110180.
  15. Skrobot J, Zair L, Ostrowski M, El Fray M. New injectable elastomeric biomaterials for hernia repair and their biocompatibility. Biomaterials. 2016;75:182–192. https://doi.org/10.1016/j.biomaterials.2015.10.037.
  16. Pramudya I, Chung H. Recent progress of glycopolymer synthesis for biomedical applications. Biomaterials Science. 2019;7(12):4848–4872. https://doi.org/10.1039/c9bm01385g.
  17. Frazar EM, Shah RA, Dziubla TD, Hilt JZ. Multifunctional temperature-responsive polymers as advanced biomaterials and beyond. Journal of Applied Polymer Science. 2020;137(25). https://doi.org/10.1002/app.48770.
  18. Diez-Escudero A, Espanol M, Ginebra MP. Synthetic bone graft substitutes: Calcium-based biomaterials. In: Alghamdi H, Jansen J, editors. Dental implants and bone grafts: materials and biological issues. Woodhead Publishing; 2020. pp. 125–157. https://doi.org/10.1016/B978-0-08-102478-2.00006-4.
  19. Stoop R. Smart biomaterials for tissue engineering of cartilage. Injury. 2008;39(1):77–87. https://doi.org/10.1016/j.injury.2008.01.036.
  20. Renth AN, Detamore MS. Leveraging “raw materials” as building blocks and bioactive signals in regenerative medicine. Tissue Engineering. Part B: Reviews. 2012;18(5):341–362. https://doi.org/10.1089/ten.teb.2012.0080.
  21. Dziki JL, Badylak SF. Acellular biologic scaffolds in regenerative medicine: unacceptable variability with acceptable results. Regenerative Engineering and Translational Medicine. 2019;5(4):414–419. https://doi.org/10.1007/s40883-019-00106-5.
  22. Gilmore B, Jackson KL, Migaly J. New innovations in anal fistula surgery. Seminars in Colon and Rectal Surgery. 2019;30(4). https://doi.org/10.1016/j.scrs.2019.100707.
  23. Xu Y, Chen C, Hellwarth PB, Bao X. Biomaterials for stem cell engineering and biomanufacturing. Bioactive Materials. 2019;4:366–379. https://doi.org/10.1016/j.bioactmat.2019.11.002.
  24. No YJ, Castilho M, Ramaswamy Y, Zreiqat H. Role of biomaterials and controlled architecture on tendon/ligament repair and regeneration. Advanced Materials. 2019;32(18). https://doi.org/10.1002/adma.201904511.
  25. Xue H, Hu L, Xiong Y, Zhu X, Wei C, Cao F, et al. Quaternized chitosan-Matrigel-polyacrylamide hydrogels as wound dressing for wound repair and regeneration. Carbohydrate Polymers. 2019;226. https://doi.org/10.1016/j.carbpol.2019.115302.
  26. Koca EI, Bozdag G, Cayli G, Kazan D, Hatir PC. Thermoresponsive hydrogels based on renewable resources. Journal of Applied Polymer Science. 2019;137(28). https://doi.org/10.1002/app.48861.
  27. Jo H, Yoon M, Gajendiran M, Kim K. Recent strategies in fabrication of gradient hydrogels for tissue engineering applications. Macromolecular Bioscience. 2020;20(3). https://doi.org/10.1002/mabi.201900300.
  28. Xue J, Wang X, Wang E, Li T, Chang J, Wu C. Bioinspired multifunctional biomaterials with hierarchical microstructure for wound dressing. Acta Biomaterialia. 2019;100:270–279. https://doi.org/10.1016/j.actbio.2019.10.012.
  29. Ghosh A, Grosvenor AJ, Dyer JM. Marine Spongia collagens: Protein characterization and evaluation of hydrogel films. Journal of Applied Polymer Science. 2019;136(39). https://doi.org/10.1002/app.47996.
  30. Li Y-CE. Sustainable biomass materials for biomedical applications. ACS Biomaterials Science and Engineering. 2019;5(5):2079–2092. https://doi.org/10.1021/acsbiomaterials.8b01634.
  31. Bartolomeu F, Dourado N, Pereira F, Alves N, Miranda G, Silva FS. Additive manufactured porous biomaterials targeting orthopedic implants: A suitable combination of mechanical, physical and topological properties. Materials Science and Engineering C. 2020;107. https://doi.org/10.1016/j.msec.2019.110342.
  32. Tao F, Cheng Y, Shi X, Zheng H, Du Y, Xiang W, et al. Applications of chitin and chitosan nanofibers in bone regenerative engineering. Carbohydrate Polymers. 2020;230. https://doi.org/10.1016/j.carbpol.2019.115658.
  33. Hassanein N, Bougherara H, Amleh A. In- vitro evaluation of the bioactivity and the biocompatibility of a novel coated UHMWPE biomaterial for biomedical applications. Journal of the Mechanical Behavior of Biomedical Materials. 2020;101. https://doi.org/10.1016/j.jmbbm.2019.103409.
  34. Dong R, Ma PX, Guo B. Conductive biomaterials for muscle tissue engineering. Biomaterials. 2020;229. https://doi.org/10.1016/j.biomaterials.2019.119584.
  35. Kumar S, Nehra M, Kedia D, Dilbaghi N, Tankeshwar K, Kim K-H. Nanotechnology-based biomaterials for orthopaedic applications: Recent advances and future prospects. Materials Science and Engineering C. 2020;106. https://doi.org/10.1016/j.msec.2019.110154.
  36. Chen Q, Lianga S, Thouas GA. Elastomeric biomaterials for tissue engineering. Progress in Polymer Science. 2013;38(3–4):584–671. https://doi.org/10.1016/j.progpolymsci.2012.05.003.
  37. Glowacki J, Mizuno S. Collagen scaffolds for tissue engineering. Biopolymers. 2008;89(5):338–344. https://doi.org/10.1002/bip.20871.
  38. Cen L, Liu W, Cui L, Zhang W, Cao Y. Collagen tissue engineering. Development of novel biomaterials and applications. Pediatric Research. 2008;63(5):492–496. https://doi.org/10.1203/PDR.0b013e31816c5bc3.
  39. Chaudhari AA, Vig K, Baganizi DR, Sahu R, Dixit S, Dennis V, et al. Future prospects for scaffolding methods and biomaterials in skin tissue engineering: A review. International Journal of Molecular Sciences. 2016;17(12). https://doi.org/10.3390/ijms17121974.
  40. Strauss K, Chmielewski J. Advances in the design and higher-order assembly of collagen mimetic peptides for regenerative medicine. Current Opinion in Biotechnology. 2017;46:34–41. https://doi.org/10.1016/j.copbio.2016.10.013.
  41. Tonndorf R, Aibibu D, Cherif C. Collagen multifilament spinning. Materials Science and Engineering C. 2020;106. https://doi.org/10.1016/j.msec.2019.110105.
  42. Song JE, Tian J, Kook YJ, Thangavelu M, Choi JH, Khang G. A BMSCs-laden quercetin/duck’s feet collagen/hydroxyapatite sponge for enhanced bone regeneration. Journal of Biomedical Materials Research – Part A. 2020;108(3):784–794. https://doi.org/10.1002/jbm.a.36857.
  43. Mikael PE, Udangawa R, Sorci M, Cress B, Shtein Z, Belfort G, et al. Production and characterization of recombinant collagen-binding resilin nanocomposite for regenerative medicine applications. Regenerative Engineering and Translational Medicine. 2019;5(4):362–372. https://doi.org/10.1007/s40883-019-00092-8.
  44. Raz P, Brosh T, Ronen G, Tal H. Tensile properties of three selected collagen membranes. Biomed Research International. 2019;2019. https://doi.org/10.1155/2019/5163603.
  45. Raghunath J, Rollo J, Sales KM, Butler PE, Seifalian AM. Biomaterials and scaffold design: Key to tissue-engineering cartilage. Biotechnology and Applied Biochemistry. 2007;46(2):73–84. https://doi.org/10.1042/BA20060134.
  46. Yang C, Xu L, Zhou Y, Zhang X, Huang X, Wang M, et al. A green fabrication approach of gelatin/CM-chitosan hybrid hydrogel for wound healing. Carbohydrate Polymers. 2010;82(4):1297–1305. https://doi.org/10.1016/j.carbpol.2010.07.013.
  47. Jangamreddy JR, Haagdorens MKC, Mirazul Islam M, Lewis P, Samanta A, Fagerholm P, et al. Short peptide analogs as alternatives to collagen in pro-regenerative corneal implants. Acta Biomaterialia. 2018,69:120–130. https://doi.org/10.1016/j.actbio.2018.01.011.
  48. Rodriguez-Rodriguez R, Espinosa-Andrews H, Velasquillo-Martinez C, Garcia-Carvajal ZY. Composite hydrogels based on gelatin, chitosan and polyvinyl alcohol to biomedical applications: a review. International Journal of Polymeric Materials and Polymeric Biomaterials. 2020;69(1):1–20. https://doi.org/10.1080/00914037.2019.1581780.
  49. Vainieri ML, Lolli A, Kops N, D’Atri D, Eglin D, Yayon A, et al. Evaluation of biomimetic hyaluronic-based hydrogels with enhanced endogenous cell recruitment and cartilage matrix formation. Acta Biomaterialia. 2020;101:293–303. https://doi.org/10.1016/j.actbio.2019.11.015.
  50. Zhu Y, Zhang F, Linhardt RJ. Heparin contamination and issues related to raw materials and controls. In: Sasisekharan R, Lee SL, Rosenberg A, Walker LA, editors. The science and regulations of naturally derived complex drugs. Cham: Springer; 2019. pp. 191–206. https://doi.org/10.1007/978-3-030-11751-1_11.
  51. Santos MH, Silva RM, Dumont VC, Neves JS, Mansur HS, Heneine LGD. Extraction and characterization of highly purified collagen from bovine pericardium for potential bioengineering applications. Materials Science and Engineering C. 2013;33(2):790–800. https://doi.org/10.1016/j.msec.2012.11.003.
  52. Liu L, Fishman ML, Hicks KB, Kende M. Interaction of various pectin formulations with porcine colonic tissues. Biomaterials. 2005;26(29):5907–5916. https://doi.org/10.1016/j.biomaterials.2005.03.005.
  53. Baldwin M, Snelling S, Dakin S, Carr A. Augmenting endogenous repair of soft tissues with nanofibre scaffolds. Journal of the Royal Society Interface. 2018;15(141). https://doi.org/10.1098/rsif.2018.0019.
  54. Geng X, Liu B, Liu J, Liu D, Lu Y, Sun X, et al. Interfacial tissue engineering of heart regenerative medicine based on soft cell-porous scaffolds. Journal of Thoracic Disease. 2018;10(20):S2333–S2345. https://doi.org/10.21037/jtd.2018.01.117.
  55. Ruprai H, Shanu A, Mawad D, Hook JM, Kilian K, George L, et al. Porous chitosan adhesives with L-DOPA for enhanced photochemical tissue bonding. Acta Biomaterialia. 2020;101:314–326. https://doi.org/10.1016/j.actbio.2019.10.046.
  56. Analiz rossiyskogo i mezhdunarodnogo rynka biomeditsiny: tekhnologicheskie i rynochnye trendy [Analysis of the Russian and international biomedicine markets: technological and market trends] [Internet]. [cited 2019 Dec 15]. Available from: https://healthnet.academpark.com/images/bio_medicine.pdf.
  57. Volodin SN, Kirillov BA. Russian market of biomedical technologies: advantages, complications and investng opportunities. Valyutnoe regulirovanie. Valyutnyy kontrol’ [Currency regulation. Foreign exchange control]. 2017;(11):50–58. (In Russ.).
  58. The proceedings of International congress “Biotechnology: state of the art and perspectives”. Moscow; RED GROUP; 2019. p. 604. (In Russ.).
  59. Coentro JQ, De Pieri A, Gaspar D, Tsiapalis D, Zeugolis DI, Bayon Y. Translational research symposium-collaborative efforts as driving forces of healthcare innovation. Journal of Materials Science: Materials in Medicine. 2019;30(12). https://doi.org/10.1007/s10856-019-6339-2.
How to quote?
Patshina MV, Voroshilin RA, Osintsev AM. Global Biomaterials Market: Potential Opportunities for Raw Materials of Animal Origin. Food Processing: Techniques and Technology. 2021;51(2):270–289. (In Russ.). https://doi.org/10.21603/2074- 9414-2021-2-270-289.
About journal

Download
Contents
Abstract
Keywords
References