Affiliation
a Kemerovo Institute of Food Science and Technology(University)
b FSBEI HVE «Kemerovo State Agricultural Institute»
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Abstract
A nanosorbent has been developed as a biologically active additive (BAA) referred to as «Gutta Viva», with sorption activity due to compositional combination of the two enterosorbents: Polysorbate 95 produced on the basis of modified low-energy citrus pectin and Aerosil produced using nanostructures of silicon dioxide. Based on the study of organoleptic and physical-chemical, sanitary- hygienic and sanitary-toxicological characteristics, regulated BAA quality indices, timing, and storage modes have been defined. Clinical trials of the specialized product by its inclusion in the diet of patients with gastrointestinal salmonellosis have been carried out. A comparative study showed intoxication syndrome reduction in patients with acute infectious gastrointestinal disease while receiving «Gutta Viva» complex. The rate of toxin elimination from the body, because of three-time intake of «Gutta Viva», was significantly superior to that of therapy without the nanosorbent. Intake of the recommended daily serving ensures the supply of 450 mg of soluble dietary fibers, representing 2.3% of the recommended level of consumption. The results proved the efficiency and functional orientation of the tested enterosorbent against endo- and exotoxins, microbial cells adsorbed on its surface and eliminated via the gastrointestinal tract. The technical documentation for the new product has been developed and approved, the expert opinions of the Institute of nutrition of Russian Academy of Medical Sciences and the Russian Ministry of health, were received which served as the basis for its inclusion in the Federal Register of biologically active additives and commercial production.
Keywords
Enterosorbent,
nanotechnology,
biologically active additive,
efficiency,
functional orientation
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