Abstract

Introduction. The problem of micronutrient deficiency remains a relevant issue all over the world. However, it is mostly developed countries that practice food fortification. The FAO and the WHO accumulate related experience and summarize it in various documents. Yet some aspects of the problem can be solved on state level. The present research featured micronutrient deficit and preventive measures in several countries taking into account local food traditions. Since 1920, a number of industrially developed northern countries have started developing and implementing various food fortification programs. Similar programs are being introduced in East, Central, and South Africa and Southeast Asia. For 40 years, Russia has been taking various measures to prevent micronutrient deficiency and related diseases.
Results and discussion. The research revealed the social and economic measures of food fortification that were found lacking in these countries. The main problem proved to be iodine, iron, and vitamin A deficiency. However, lack of other micronutrients also remains a burning issue. The present paper gives an overview of iodine, selenium, and iron deficiencies in several countries. The authors proposed several solutions, e.g. food group selection, food additives (mono or premix), various ways of fortification, etc. The article also contains a list of main Russian regulatory documents that control the production and turnover of food fortification. The authors showed advantages of food fortification of mass consumption products, e.g. the low cost of processing, the affordability of enriched products, their availability for different social population, the well-developed regulation standards, the good social effect of food fortification projects, their economic efficiency, etc. Taking into consideration the environmental changes and various geopolitical and economic factors that negatively affect nutrition and population health, the authors recommend to continue evidence-based research in this direction to develop new technologies and food supplements.
Conclusion. The novelty of the research lies in the fact that it reveals priority areas for prospective scientific research in food fortification based on a thorough analysis of the existing experience. From the point of view of practical application, the research offers a deeper understanding of the problem, stresses its relevance, sets goals and objectives of future studies, and offers some ideas for preventive programs.

Keywords

Micronutrients, deficiency, nutritional value enhancement, food supplementation, iodine, selenium, iron, legal framework

REFERENCES

1. Zhminchenko VM, Gapparov MMG. Modern trends of research in nutritiology and nutrition hygiene. Problems of Nutrition. 2015;84(1):4–14. (In Russ.).
2. World declaration and plan of action for nutrition. Rome: FAO and WHO; 1992. 50 p.
3. Food fortification: Technology and quality control. Rome: FAO; 1996. 102 p.
4. Pivina L, Semenova Yu, Dosa MD, Dauletyarova M, Bjorklund G. Iron deficiency, cognitive functions, and neurobehavioral disorders in children. Journal of Molecular Neuroscience. 2019;68(1):1–10. DOI: https://doi.org/10.1007/s12031-019-01276-1.
5. Zaitseva NV, May IV, Kiryanov DA, Goryaev DV, Kleyn SV. Social and hygienic monitoring today: state and prospects in conjunction with the risk-based supervision. Health Risk Analysis. 2016;(4):4–16. (In Russ.). DOI: https://doi.org/10.21668/health.risk/2016.4.01.
6. Alpysbayeva ZhT. Social and hygienic monitoring of labor conditions at industrial enterprises. Bulletin of the Karaganda University. Biology, Medicine, Geography Series. 2019;1(93):84–88.
7. Sharuho GV. The use of social and hygienic monitoring system in solution of micronutrient deficiency (by the example of the Tyumen region). Meditsinskaya nauka i obrazovanie Urala [Medical science and education in the Urals]. 2010;11(3)(63):153–155. (In Russ.).
8. Kodentsova VM. Food fortification of mass consumption by vitamins and minerals as a way to improve their nutritional value. Food Industry. 2014;(3):14–18. (In Russ.).
9. Kodentsova VM, Vrzhesinskaya OA. Vitamin-enriched food products in nutrition of children: background, problems and prospects. Pediatric Nutrition. 2012;10(5):31–44. (In Russ.).
10. Vidar M. International legal frameworks for food labelling and consumer rights. In: Albert J, editor. Innovations in food labelling. Cambridge: Woodhead Publishing; 2009. 17–36 p.
11. Allen L, de Benoist B, Dary O, Hurrell R. Guidelines on food fortification with micronutrients. World Health Organization and Food and Agriculture Organization of the United Nations; 2006. 376 p.
12. Sacco J. Food fortification policy in Canada. In: Preedy VR, Srirajaskanthan R, Patel VB, editors. Handbook of food fortification and health. From concepts to public health applications. Volume 1. New York: Humana Press; 2013. 59–71 p. DOI: https://doi.org/10.1007/978-1-4614-7076-2_5.
13. Sablah M, Grant F, Fiedler JL. Food fortification in Africa: Progress to date and priorities moving forward. Sight and Life. 2013;27(3):18–24.
14. Zimbabwe launches national food fortification strategy [Internet]. [cited 2020 Jan 10]. Available from: https://www.afro. who.int/news/zimbabwe-launches-national-food-fortification-strategy.
15. Dijkhuizen MA, Wieringa FT, Soekarjo D, Van KT, Laillou A. Legal framework for food fortification: Examples from Vietnam and Indonesia. Food and Nutrition Bulletin. 2013;34(2):112–123.
16. Isabelle M, Chan P, Wijaya SY. Report on Regulatory status of micronutrient fortification in southeast Asia. International Life Sciences Institute Southeast Asia Region Report Series; 2011. 32 p.
17. Gayer J, Smith G. Micronutrient fortification of food in southeast Asia: Recommendations from an expert workshop. Nutrients. 2015;7(1):646–658. DOI: https://doi.org/10.3390/nu7010646.
18. Khanh NTM, Trang NT, Manh LD, Quang LH. New strain Saccharomyces cerevisiae A112 for the production of zinc-fortified biomass. Food Processing: Techniques and Technology. 2018;48(4):114–120. (In Russ.). DOI: https://doi.org/10.21603/2074-9414-2018-4-114-120.
19. Mayurnikova LA, Novoselov SV, Bolkhovitina EN. Formirovanie potrebitelʹskikh predpochteniy k novatsionnym produktam pitaniya v regionalʹnykh usloviyakh [Formation of consumer preferences for innovative food products in regional conditions]. Polzunovsky Vestnik. 2010;(4–2):13–19. (In Russ.).
20. Kornen NN, Viktorova EP, Evdokimova OV. Methodological approaches to the creation of healthy food. Problems of Nutrition. 2015;84(1):95–99. (In Russ.).
21. Tretyak LN, Javkina DI. Additional requirements to quality and safety at choosing additives for food products enrichment. Food Industry. 2018;(5):18–21. (In Russ.).
22. Bollinedi H, Dhakane-Lad J, Gopala Krishnan S, Bhowmick PK, Prabhu KV, Singh NK, et al. Kinetics of β-carotene degradation under different storage conditions in transgenic Golden Rice® lines. Food Chemistry. 2019;278:773–779. DOI: https://doi.org/10.1016/j.foodchem.2018.11.121.
23. Chandrasekar Rajendran SC, Chamlagain B, Kariluoto S, Piironen V, Saris PEJ. Biofortification of riboflavin and folate in idli batter, based on fermented cereal and pulse, by Lactococcus lactis N8 and Saccharomyces boulardii SAA655. Journal of Applied Microbiology. 2017;122(6):1663–1671. DOI: https://doi.org/10.1111/jam.13453.
24. Kodentsova VM, Vrzhesinskaya OA, Risnik DV, Nikityuk DB, Tutelyan VA. Micronutrient status of population of the Russian Federation and possibility of its correction. State of the problem. Problems of Nutrition. 2017;86(4):113–124. (In Russ.).
25. Gerasimov GA. On WHO Guidelines “Fortification of food grade salt with iodine for the prevention and control of iodine deficiency disorders”. Clinical and experimental thyroidology. 2014;10(4):5–8. (In Russ.). DOI: https://doi.org/10.14341/ket201445-8.
26. Trichina VV, Mayurnikova LA, Novoselov SV. The integrated method of development of specialized products for the correction of nutrition of personnel working in hazardous conditions. Bulletin of South Ural State University. Series: Food and Biotechnology. 2015;3(4):94–106. (In Russ.). DOI: https://doi.org/10.14529/food150413.
27. Ethgen O, Hiligsmann M, Burlet N, Reginster J-Y. Cost-effectiveness of personalized supplementation with vitamin D-rich dairy products in the prevention of osteoporotic fractures. Osteoporosis International. 2016;27(1):301–308. DOI: https://doi.org/10.1007/s00198-015-3319-3.
28. Hiligsmann M, Burlet N, Fardellone P, Al-Daghri N, Reginster J. Public health impact and economic evaluation of vitamin D-fortified dairy products for fracture prevention in France. Osteoporosis International. 2017;28(3):833–840. DOI: https://doi.org/10.1007/s00198-016-3786-1.
29. Sandmann A, Amling M, Barvencik F, König H-H, Bleibler F. Economic evaluation of vitamin D and calcium food fortification for fracture prevention in Germany. Public Health Nutrition. 2017;20(10):1874–1883. DOI: https://doi.org/10.1017/S1368980015003171.
30. Allen RE, Dangour AD, Tedstone AE, Chalabi Z. Does fortification of staple foods improve vitamin D intakes and status of groups at risk of deficiency? A United Kingdom modeling study. American Journal of Clinical Nutrition. 2015;102(2):338–382. DOI: https://doi.org/10.3945/ajcn.115.107409.
31. Towo E, Mgoba C, Assey V, Kaishozi G. Food fortification strategy to control micronutrient deficiencies in Tanzania. European Journal of Nutrition and Food Safety. 2015;5(5):427–428. DOI: https://doi.org/10.9734/EJNFS/2015/20893.
32. Andersson M, de Benoist B, Darnton-Hill I, Delange F. Iodine deficiency in Europe: A continuing public health problem. World Health Organization; 2007. 86 p.
33. Delange F, Burgi H, Chen ZP, Dunn JT. World status of monitoring of iodine deficiency disorders control programs. Thyroid. 2002;12(10):915–924. DOI: https://doi.org/10.1089/105072502761016557.
34. Kelly FC, Snedden WW. Prevalence and geographical distribution of endemic goitre. Bulletin of the World Health Organization. 1958;18(1–2):5–173.
35. Delange F, Dunn JT, Glinoer D. Iodine deficiency in Europe. A continuing concern. New York: Plenum Press; 1993. 492 p.
36. Global prevalence of iodine deficiency disorders. World Health Organization; 1993. 80 p.
37. Melnichenko GA, Troshina EA, Platonova NM, Panfilova EA, Rybakova AA, Abdulkhabirova FM, et al. Iodine deficiency thyroid disease in the Russian Federation: the current state of the problem. Analytical review of publications and data of official state statistics (Rosstat). Consilium Medicum. 2019;21(4):14–20 (In Russ.).
38. Flachowsky G. Iodine in animal nutrition and Iodine transfer from feed into food of animal origin. Lohmann Information. 2007;42(2):47–59.
39. Solovyev N, Vanhaecke F, Michalke B. Selenium and iodine in diabetes mellitus with a focus on the interplay and speciation of the elements. Journal of Trace Elements in Medicine and Biology. 2019;56:69–80. DOI: https://doi.org/10.1016/j.jtemb.2019.07.005.
40. Zhang L, Hu B, Deng K, Gao X, Sun G, Zhang Z, et al. NRT1.1B improves selenium concentrations in rice grains by facilitating selenomethinone translocation. Plant Biotechnology Journal. 2019;17(6):1058–1068. DOI: https://doi.org/10.1111/pbi.13037.
41. Wrobel JK, Power R, Toborek M. Biological activity of selenium: Revisited. IUBMB Life. 2016;68(2):97–105. DOI: https://doi.org/10.1002/iub.1466.
42. Davydenko NI, Mayurnikova LA. On the possibility to grow high-selenium wheat in the Kuznetsk basin. Foods and Raw Materials. 2014;2(1):3–10. DOI: https://doi.org/10.12737/4089.
43. Newman R, Waterland N, Moon Y, Tou JC. Selenium biofortification of agricultural crops and effects on plant nutrients and bioactive compounds important for human health and disease prevention – a review. Plant Foods for Human Nutrition. 2019;74(4):449–460. DOI: https://doi.org/10.1007/s11130-019-00769-z.
44. Alfthan G, Eurola M, Ekholm P, Venalainen E-R, Root T, Korkalainen K, et al. Effects of nationwide addition of selenium to fertilizers on foods, and animal and human health in Finland: From deficiency to optimal selenium status of the population. Journal of Trace Elements in Medicine and Biology. 2015;31:142–147. DOI: https://doi.org/10.1016/j.jtemb.2014.04.009.
45. Weekley CM, Harris HH. Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease. Chemical Society Reviews. 2013;42(23):8870–8894. DOI: https://doi.org/10.1039/c3cs60272a.
46. Brozmanova J, Manikova D, Vlckova V, Chovanec M. Selenium: a double-edged sword for defense and offence in cancer. Archives of Toxicology. 2010;84(12):919–938. DOI: https://doi.org/10.1007/s00204-010-0595-8.
47. Zhan X, Qie Y, Wang M, Li X, Zhao R. Selenomethionine: an effective selenium source for sow to improve Se distribution, antioxidant status, and growth performance of pig offspring. Biological Trace Element Research. 2011;142(3):481–491. DOI: https://doi.org/10.1007/s12011-010-8817-8.
48. Kouba A, Velisek J, Stara A, Masojidek J, Kozak P. Supplementation with sodium selenite and selenium-enriched microalgae biomass show varying effects on blood enzymes activities, antioxidant response, and accumulation in common barbel (Barbus barbus). BioMed Research International. 2014;2014. DOI: https://doi.org/10.1155/2014/408270.
49. Fairweather-Tait SJ, Bao Y, Broadley MR, Collings R, Ford D, Hesketh JE, et al. Selenium in human health and disease. Antioxidants and Redox Signaling. 2011;14(7):1337–1383. DOI: https://doi.org/10.1089/ars.2010.3275.
50. Rayman MP. Selenium and human health. The Lancet. 2012;379(9822):1256–1268. DOI: https://doi.org/10.1016/S0140-6736(11)61452-9.
51. Shchigartsova VV. Foodstuffs enrichment with selenium. Obrazovanie i nauka bez granits: sotsialʹnogumanitarnye nauki [Education and science without borders: social sciences and humanities]. 2017;(6):249–252. (In Russ.).
52. Bazhenova BA, Balzhinimaeva SK, Danilov MB. Selenium enriched pate. Food Industry. 2012;(2):12–14. (In Russ.).
53. Tsvetkova OA. Mediko-sotsialʹnye aspekty zhelezodefitsitnoy anemii [Medical and social aspects of iron deficiency anemia]. Russian Medical Journal. 2009;17(5):387–390. (In Russ.).
54. Lotfi M, Mannar MGV, Merx RJHM, Naber-van den Heuvel P. Micronutrient fortification of foods. Current practices, research, and opportunities. The Micronutrient Initiative/ International Agricultural Centre; 1996. 118 p.
55. Guideline: fortification of rice with vitamins and minerals as a public health strategy. Geneva: World Health Organization; 2018. 62 p.