ISSN 2074-9414 (Print),
ISSN 2313-1748 (Online)

Formula and Technology Development for Obtaining Biologically Active Natural Food Additives

The research featured the development of formulae and technologies for the production of biologically active additives (BAA) for functional foods with potential adaptogenic, antioxidant, and hepatoprotective properties. Shilajit, a natural mineral-organic substrate, and various plant materials were used as sources of natural biologically active substances (BAS). The relevance of the study comes from the need for more efficient use of natural biologically active compounds, as well as from the need to expand the range of domestic dietary supplements with natural ingredients, which resulted from the current import substitution. Scientific data and experimental studies made it possible to choose advantageous raw materials with BAS and to assess their safety and potential properties. An experiment determined the content of BAS in the raw materials and in the control samples. A compatibility test wasconducted by mixing. As a result, five formulae with various combinations of natural components in the composition were scientifically substantiated. The authors defined the physicochemical and technological properties of the mixtures of dry extracts that determined the choice of technology and the quality of the finished product. The present paper also describes technology of obtaining encapsulated dietary supplements based on dry extracts of medicinal plants and shilajit. The advantage of the technology lies in the use of natural components and special processing methods of BAS preservation. The research included the method of water-activated granulation while 20% ethyl was used as a wetting agent. To obtain the granulate, lactose (Russia) and AEROSIL® 200 Pharma (Evonik Industries, Germany) were used as additive agents. As a result, capsules with a dosage of 700 mg were developed. The BAA can be produced on food and pharmaceutical plants.
  1. Poznjakovsky V.M. and Sukhanov B.P. Biologically active additives in a modern food. Food Processing: Techniques and Technology, 2009, vol. 13, no. 2, pp. 44–50. (In Russ.).
  2. Poznyakovskiy V.M., Gurʹyanov Yu.G., and Bebenin V.V. Pishchevye i biologicheski aktivnye dobavki: kharakteristika, primenenie, kontrolʹ [Food and dietary supplements: characteristics, application, and control]. Kemerovo: Kuzbassvuzizdat Publ., 2011. 275 p. (In Russ.).
  3. Petrenko A.S., Ponomareva M.N., and Sukhanov B.P. Regulation of food supplements In the European Union and its member States. Part I. Problems of Nutrition, 2014, vol. 83, no. 3, pp. 32–40. (In Russ.).
  4. Tutelʹyan V.A., Ehller K.I., Aristarkhova T.V., et al. Metody analiza minornykh biologicheski aktivnykh veshchestv pishchi[Methods of analysis of minor biologically active food substances]. Moscow: Dynasty Publ., 2010. 180 p. (In Russ.).
  5. Tutelyan V.A., Kiseleva T.L., Kochetkova A.A., et al. Promising source of micronutrients for specialized foods with modified carbohydrate profile: traditional medicine experience. Problems of Nutrition, 2016, vol. 85, no. 4, pp. 46–60. (In Russ.).
  6. Novikov V.S., Karkishchenko V.N., and Shustov E.B. Funktsionalʹnoe pitanie cheloveka pri ehkstremalʹnykh vozdeystviyakh[Functional foods for a person under extreme conditions]. St. Petersburg: Polytechnic-print Publ., 2017. 346 p. (In Russ.).
  7. Karkishchenko N.N., Uyba V.V., Karkishchenko V.N., et al. Ocherki sportivnoy farmakologii. Tom 3. Vektory farmakoregulirovaniya [Essays on sports pharmacology. Vol. 3. Pharmacy and regulation vectors]. St. Petersburg: Aising Publ., 2014. 356 p. (In Russ.).
  8. Cropley M., Banks A.P., and Boyle J. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms. Phytotherapy Research, 2015, vol. 29, no. 12, pp. 1934–1939. DOI:
  9. Prikolab F.I. Aktivnye veshchestva iz rasteniy, zapuskayushchie mitokhondrialʹnyy putʹ apoptoza [Active substances from plants that trigger the mitochondrial pathway of apoptosis]. Problems of Nutrition, 2016, vol. 85, no. S2, pp. 240–241. (In Russ.).
  10. Wang Z.Y., Liu J.G., Li H., and Yang H.-M. Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer’s Disease: A Review. American Journal of Chinese Medicine, 2016, vol. 44, no. 8, pp. 1525–1541. DOI:
  11. Mayurnikova L.A., Zinchuk S.F., Davydenko N.I., and Gilmulina S.A. Development of a functional basis of phyto- beverages with an increased antioxidant activity for the correction of nutrition of patients with diabetes mellitus. Foods and Raw Materials, 2017, vol. 5, no. 2, pp. 178–188. DOI:
  12. Babiy N.V., Pomozova V.A., and Pekov D.B. Development considerations for tonic beverages enhancing the body resistance. Food Processing: Techniques and Technology, 2016, vol. 41, no. 2, pp. 13–20. (In Russ.).
  13. Nader A. Razrabotka tverdykh lekarstvennykh form ehkstrakta imbirya lekarstvennogo. Dis. kand. farm. nauk [Development of solid dosage forms of ginger extract. Dis. Cand. Farm. Sci]. Moscow, 2017. 24 p.
  14. Tereshkova E.S., Batashov E.S., and Sevodin V.P. The fruits of goji (Lycium Barbarum L.) are a promising raw material for production of zeaxanthin (E161H). Food Processing: Techniques and Technology, 2015, vol. 39, no. 4, pp. 93–98. (In Russ.).
  15. Vitamins and Dietary Supplements – USA. Country report-Euromonitor International, 2010.
  16. Gerasimov E.M., Tretʹyak L.N., Yachevskiy V.N., and Skalʹnyy A.V. Vliyanie antistressovykh sportivnykh napitkov na vosstanovlenie rabotosposobnosti posle myshechnykh peregruzok [The effect of anti-stress sports drinks on the restoration of performance after muscle overloads]. Journal of Restorative Medicine & Rehabilitation, 2011, vol. 45, no. 5, pp. 16–20. (In Russ.).
  17. Petrov V.I., Spasova A.A., Nedogoda S.V., et al. Rossiyskaya ehntsiklopediya biologicheski aktivnykh dobavok k pishche[Russian encyclopedia of biologically active additives]. Moscow: GEOTAR – Media Publ., 2007. 1052 p. (In Russ.).
  18. Frolova L.N. and Kiseleva T.L. Biological activity of mummie Publication. Traditional medicine, 2010, vol. 23, no. 4, pp. 34–40. (In Russ.).
  19. Smertina E.S., Fedyanina L.N., Zinatyllina C.F., and Lyah V.A. Evaluation of the use of plant adaptogen as a functional ingredient for creating bread of therapeutic and prophylactic purpose. Food Processing: Techniques and Technology, 2014, vol. 33, no. 2, pp. 88–92. (In Russ.).
  20. Subbotina M.A. and Dolgolyuk I.V. Study of composition and biological value of pinon kernel of Siberian pine. Food and Raw Materials, 2015, vol. 3, no. 1, pp. 56–61. DOI:
  21. Frolova N.A., Reznichenko I.Y., and Ivankina N.F. Technology and evaluation of hard-boiled sweets enriched with biologically active plant and animal raw materials extracts. Food Processing: Techniques and Technology, 2012, vol. 27, no. 4, pp. 164–170. (In Russ.).
  22. Shkolnikova M.N., Averyanova E.V., Donya D.V., and Khlopotov I.V. Development of composition and technology for production of nonalcoholic beverage concentrate tablet. Food Processing: Techniques and Technology, 2017, vol. 46, no. 3, pp. 96–101. (In Russ.). DOI:
  23. Edinye sanitarno-ehpidemiologicheskie i gigienicheskie trebovaniya k tovaram, podlezhashchim sanitarno- ehpidemiologicheskomu nadzoru (kontrolyu) [The unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)]. Moscow, 2010. 352 p.
  24. Tutel’yan V.A. and Sukhanov B.P. Modern approaches to the maintenance of quality and safety of biologically active additivies in the Russian Federation. Pacific Medical Journal, 2009, vol. 35, no. 1, pp. 12–19. (In Russ.).
  25. Khodzhava M.V., Demina N.B., Skatkov S.A., and Kemenova V.A. Technological aspects of moisture-activated granulation. Pharmacy, 2013, no. 1, pp. 34–36. (In Russ.).
  26. Pavlov V.M., Chekhani N.R., and Pavlova L.A. Technology of granulation of dry extracts by moisture-activated dry granulation with kleptose as an excipient. Modern problems of science and education, 2014, no. 5, pp. 762. (In Russ.).
  27. Alekseev K.V., Kedik S.A., Blynskaya E.V., Alekseev V.K., and Maslennikova N.V. Farmatsevticheskaya tekhnologiya[Pharmaceutical technology]. Moscow: ZAO IFT Publ., 2015. 672 p. (In Russ.).
How to quote?
About journal