Аннотация

Контроль за содержанием антибиотиков группы амфениколы в животноводческой продукции – важная задача пищевой промышленности. Их попадание и накопление в организме человека приводит к появлению устойчивости к действию антимикробных препаратов, используемых в лечении инфекционных заболеваний. Цель работы – обобщение и анализ научных публикаций, посвященных методам идентификации остаточных следов антибиотиков группы амфениколы в молоке и молочной продукции.
В ходе работы проанализированы научные статьи российских и зарубежных ученых за последние 6 лет, размещенные в базах данных PubMed от National Center for Biotechnology Information (США), Scopus и ScienceDirect от Elsevier, на платформе Web of Science и в отечественной электронной библиотеке eLibrary.Ru.
Анализ научной литературы показал, что амфениколы широко используются в сельском хозяйстве. Опасные остаточные антибиотические вещества попадают в организм человека с пищей животного происхождения (молоко). Представлена информация об основных методах определения данных антибиотиков – скрининг и количественное определение. Показано, что эффективным методом оценки являются хроматографические, а именно высокоэффективная жидкостная хроматография с различными модификациями. Данные методы не лишены проблем с пробоподготовкой сырья – молока и сложной матрицы, приводящей к закупориванию капилляра. Следовательно, перспективны исследования в области очистки данного сырья и дальнейшего выделения амфениколов.
Рассмотрены основные методы идентификации антибиотиков группы амфениколы в молоке и продуктах его переработки. Обоснована перспектива разработки новых аналитических методов выделения и анализа остаточного количества антибиотиков данной группы.

Ключевые слова

Антибиотики, амфениколы, молоко, хроматография, биосенсоры, аптасенсоры, животноводческая продукция, антибиотикорезистентность

ФИНАНСИРОВАНИЕ

Работа выполнена в рамках гранта Президента РФ при государственной поддержке ведущих научных школ (НШ-2694.2020.4).

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